A Study Comparing Viscosupplementation and Corticosteroid Injections for Knee Osteoarthritis

• Status: Unknown status
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Do differences exist between patients who receive a single intra-articular injection of corticosteroid versus patients who receive a single intra-articular injection of hyaluronic acid for the treatment of knee osteoarthritis at 1, 3 and 6 weeks, and 3 and 6 months post injection?

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: LifeMark Health
• Treatments: Hyaluronic Acid; Hylan; Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria:

• Clinical

• 19-75 years of age (inclusive)

• Symptomatic OA (1 of the following: pain, stiffness, or swelling)

• Evidence of grade I, II or III OA on radiographic images according to Kellgren-Lawrence grading scale.

Exclusion Criteria:

• Clinical

• Previous surgery on either knee (not including a diagnostic arthroscopy arthroscopy or simple partial meniscectomy)

• Intra-articular treatment within the last 3 months

• Ipsilateral cruciate or collateral ligament injury within past 3 months, or evidence of ligament laxity

• Inflamed knee or pronounced effusion

• Allergy to birds, eggs, avian proteins or known HA or corticosteroid

• Venous or lymphatic stasis

• Skin condition in the injection area

• Evidence of infection in the affected joint

• History of crystalline arthropathy or inflammatory arthritis

• Pregnant or nursing

• Third Party, Medical Legal or Workers' Compensation Board

• Patient unable to understand English or unable to providing informed consent