A Study Comparing of Two Different Chemotherapy Regimens, in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer
Status:
Completed
Trial end date:
2010-12-01
Target enrollment:
Participant gender:
Summary
This is a multicenter, open-label, randomized, two-arm Phase 2 study comparing pemetrexed
plus best supportive care with best supportive care alone as maintenance therapy following
first-line treatment with a pemetrexed-cisplatin combination in patients with advanced
non-squamous non-small cell lung cancer.
A total of approximately 100 patients are planned to be enrolled, and following completion of
four cycles of pemetrexed-cisplatin (Induction Phase) those patients in which disease
progression has not occurred will be randomized in a 2:1 ratio to one of two treatment arms
(Maintenance Phase): Arm A (pemetrexed plus best supportive care) or Arm B (best supportive
care alone).