A Study To Determine Effects Of Fluticasone Propionate On Sputum Neutrophils After Inhaled Lipopolysaccharide Challenge In Volunteers

• Status: Completed
• Trial end date: 2012-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Study to assess effect of Fluticasone Propionate on acute lung inflammation following inhaled lipopolysaccharide (LPS) challenge. Study will be conducted in healthy volunteers. Assessment of inflammation will be via sputum induction.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Pfizer
• Treatments: Fluticasone; Xhance

Criteria

Inclusion Criteria:

• Healthy volunteers

• Normoresponsive airways - histamine PC20>16mg/mL

• Able to complete sputum induction successfully

Exclusion Criteria:

• Non (or ex) smokers

• No LPS challenge in previous 4 weeks