A Study To Investigate The Effect of JNJ-39758979 on Histamine Induced Itch in Healthy Male Volunteers

• Status: Completed
• Trial end date: 2010-05-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to investigate the effect of JNJ-39758979 compared to placebo on histamine induced itch in healthy male volunteers.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
• Treatments: Cetirizine; Histamine; Histamine phosphate

Criteria

Inclusion Criteria:

• Non-smoker or ex-smoker for at least 3 months

• Should generally be in good health

• Must have negative urine alcohol and drug tests

• Must consent to utilize a medically acceptable method of contraception throughout the study and for three months after the last dose of study drug and not donate sperm during the study and for 3 months after receiving the last dose of study drug

Exclusion Criteria:

• Positive for hepatitis B, hepatitis C, or HIV

• History of drug or alcohol abuse within the past two years

• Known allergies, hypersensitivity, or intolerance to cetirizine (Zyrtec)

• Any confirmed significant reactions against any drug

• Active skin diseases

• History of atopic disease or evidence of allergen sensitization by skin prick testing to common aeroallergens

• Use of antihistamines or antidepressants with antihistamine properties within the last 7 days, prescription medication within the last 14 days or Monoamine oxidase inhibitors (MAOIs) within the last 21 days

• Have received an investigational drug or device within the past 3 months