A Study for Patients With Neurogenic Orthostatic Hypotension
Status:
Completed
Trial end date:
1999-11-24
Target enrollment:
Participant gender:
Summary
We are seeking male and female patients to voluntarily take part in a clinical research
study. Patients must be aged 18 or older and diagnosed with symptomatic orthostatic
hypotension (low blood pressure while in the upright position) due to Parkinson's disease,
multiple system atrophy, pure autonomic failure or autonomic neuropathies (i.e. neurogenic
orthostatic hypotension). Symptoms of low blood pressure include dizziness, lightheadedness,
changes in vision and generalized weakness upon standing. The main effect of the drug being
studied is to increase blood pressure in the upright position so symptoms will decrease.
The purpose of this clinical study is to further assess the clinical benefit of midodrine
hydrochloride (ProAmatine®), an approved treatment for orthostatic hypotension. During the
course of the study, participants will receive either ProAmatine® or a placebo. Assessments
will be made using questionnaires that measure symptom and activity levels. Blood pressure in
the lying down and standing positions will be measured at each visit.