A Study of ALG-000184 Drug to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Single and Multiple Doses in Healthy Volunteers and CHB Subjects

• Status: Recruiting
• Trial end date: 2022-07-01
• Target enrollment: 0
• Participant gender: All

Summary

A Randomized Study of ALG-000184 Drug to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Single and Multiple Doses in Healthy Volunteers and CHB Subjects

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Aligos Therapeutics

Criteria

Inclusion Criteria for Healthy Subjects:

1. Male and Female between 18 and 55 years old

2. Female subjects must have a negative serum pregnancy test at screening

3. Subjects must be nonsmokers for at least 3 months prior to randomization

4. BMI 18.0 to 32.0 kg/m^2

5. Subjects must have a 12-lead ECG that meets protocol criteria

Inclusion Criteria for CHB Subjects:

1. Male and Female between 18 and 65 years old

2. Female subjects must have a negative serum pregnancy test at screening

3. BMI 18.0 to 35.0 kg/m^2

4. HBeAg-negative chronic hepatitis B

5. Subjects must have a 12-lead ECG that meets protocol criteria

6. Subjects must be treatment naïve or currently not treated within 6 months prior of randomization

Exclusion Criteria for Healthy Subjects:

1. Subjects with any current or previous illness that, in the opinion of the Investigator, might confound the results of the study or pose an additional risk in administering study drug to the subject or that could prevent, limit, or confound the protocol specified assessments or study results' interpretation

2. Subjects with a past history of cardiac arrhythmias, risk factors for Torsade de Pointes syndrome (e.g., hypokalemia, family history of long QT Syndrome) or history or clinical evidence at screening of significant or unstable cardiac disease etc.

3. Subjects with a history of clinically significant drug allergy

4. Excessive use of alcohol defined as regular consumption of ≥14 units/week for women and ≥21 units/week for men

5. Unwilling to abstain from alcohol use for 48 hours prior to start of dosing through end of study follow up

6. Subjects with Hepatitis A, B, C, D, E or HIV-1/HIV-2 infection or acute infections such as SARS- CoV-2 infection

7. Subjects with renal dysfunction (e.g., estimated creatinine clearance <90 mL/min/1.73 m^2 at screening, calculated by the Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] formula)

Exclusion Criteria for CHB Subjects:

1. Subjects with any current or previous illness that, in the opinion of the Investigator, might confound the results of the study or pose an additional risk in administering study drug to the subject or that could prevent, limit, or confound the protocol specified assessments or study results' interpretation

2. Subjects with a past history of cardiac arrhythmias, risk factors for Torsade de Pointes syndrome (e.g., hypokalemia, family history of long QT Syndrome) or history or clinical evidence at screening of significant or unstable cardiac disease etc.

3. Subjects with a history of clinically significant drug allergy

4. Excessive use of alcohol defined as regular consumption of ≥14 units/week for women and ≥21 units/week for men

5. Subjects with Hepatitis A, C, D, E or HIV-1/HIV-2 infection or acute infections such as SARS- CoV-2 infection

6. Subjects with renal dysfunction (e.g., estimated creatinine clearance <70 mL/min/1.73 m^2 at screening, calculated by the Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] formula)

7. Subject with any history or current evidence of hepatic decompensation such as:

variceal bleeding, spontaneous bacterial peritonitis, ascites, hepatic encephalopathy, or active jaundice (within the last year)

8. Subjects must have absence of signs of hepatocellular carcinoma

9. Subjects positive for anti-HBs antibodies

10. History or current evidence of cirrhosis

11. Subjects with liver fibrosis that is classified as Metavir Score ≥F3 liver disease