A Study of ASN007 in Patients With Advanced Solid Tumors

• Status: Completed
• Trial end date: 2020-06-30
• Target enrollment: 0
• Participant gender: All

Summary

The study is divided into two parts. The first part of the study will test various doses of ASN007 to find out the highest safe dose to test in five specific groups. The second part of the study will test how well ASN007 can control cancer.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Asana BioSciences

Criteria

Inclusion Criteria:

• Written informed consent obtained prior to any study-related procedure being performed;

• Male or non-pregnant, non-lactating female patient at least 18 years of age at the time of consent;

• Eastern Cooperative Oncology Group Performance Status 0-1 (Part A) and PS 0-2 (Part B)

• Histologically or cytologically confirmed

• advanced or metastatic solid tumor (Part A)

• Group 1: BRAF mutant melanoma (Part B)

• Group 2: NRAS or HRAS mutant solid tumors(Part B)

• Group 3: KRAS mutant CRC.(Part B)

• Group 4: KRAS mutant NSCLC (Part B)

• Group 5: Pancreatic Ductal Adenocarcinoma (Part B)

• Progressive disease after failure of or intolerant to all available standard systemic treatments that have shown a documented benefit in overall survival for their respective tumor type.

• Measurable or evaluable disease per RECIST v1.1

• Screening hematology values of the following:

• absolute neutrophil count ≥ 1000/μL,

• platelets ≥ 100,000/μL,

• hemoglobin ≥ 9 g/dL

• Screening chemistry values of the following:

• alanine aminotransferase (ALT) and aspartate transaminase (AST) ≤ 3.0 × upper limit of the normal (ULN),

• total bilirubin ≤ 1.5 × ULN,

• creatinine ≤ 1.5 × ULN,,

• albumin ≥ 2.8 g/dL.

• Screening heart function lab test

• creatinine kinase - MB, troponin-I, and troponin-T within normal limits

• Subject is willing and able to comply with all protocol required visits and assessments, including biopsy if assigned.

Exclusion Criteria:

• Prior treatment with ASN007 or another ERK1/2 inhibitor

• Known hypersensitivity to ASN007 or its excipients;

• Part B: Prior treatment with a RAF or MEK pathway inhibitor, except BRAFmutant melanoma (Group 1)

• Prior chemotherapy, targeted therapy or monoclonal antibody therapy within 3 weeks of start of study treatment (Day1), or 5 half-lives, whichever is shorter.

• Concurrent or prior bone marrow factors (e.g. G-CSF, GM-CSF or erythropoietin) within 3 weeks prior to Day 1 of treatment.

• Febrile neutropenia or serious persistent infection within 2 weeks prior to Day 1 of treatment

• Failure to recover from major surgery or traumatic injury within 4 weeks or minor surgery within 2 weeks prior to Day 1 of treatment.

• History of or current evidence / risk of retinal vein occlusion (RVO) central serous retinopathy (CSR), or glaucoma with intraocular pressures ≥ 21 mmHg or other pre-existing ocular conditions that may put the patient at risk for ocular toxicities

• Known central nervous system (CNS) primary tumor, CNS metastases or carcinomatous meningitis (Part A). Patients may be enrolled with CNS metastasis in certain circumstances in Part B.

• Clinically significant heart disorders including an ejection fraction of < 50%

• Other serious uncontrolled conditions such as fungal, bacterial or viral infection; HIV, Hepatitis B or C, bleeding disorders, interstitial lung disease,

• Any other condition that might place the patient at undue risk.