A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)

• Status: Recruiting
• Trial end date: 2028-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic
• Collaborator: National Heart, Lung, and Blood Institute (NHLBI)
• Treatments: Amlodipine; Losartan

Criteria

Inclusion Criteria:

• B/S1 hypertension; SBP 120-139 average based on 3 office measurements.

• COA Repair prior to age 10

• No residual COA; Based on mean doppler COA gradient <20mmHg within past 12 months

Exclusion Criteria:

• Currently on beta blocker (BB) therapy

• Pregnancy/lactating

• eGFR<30

• Hyperkalemia (serum potassium >5.5mmol/L)

• Severe Aortic or Mitral valve stenosis or regurgitation

• Epicardial CAD diagnosis

• Received antihypertensive medications within the past year