A Study of Aspirin and Clopidogrel in Patients With Idiopathic Pulmonary Arterial Hypertension
Status:
Completed
Trial end date:
2003-12-01
Target enrollment:
Participant gender:
Summary
Rationale: Idiopathic pulmonary arterial hypertension (IPAH) is characterized by in situ
thrombosis and increased thromboxane A2 (Tx-M) synthesis. While both may be attributable to
abnormal platelet function, there are no studies of anti-platelet therapy in IPAH.
Objectives: The purpose of this study is to assess the effects of aspirin (ASA) and
clopidogrel on platelet function and eicosanoid metabolism in patients with IPAH.
Phase:
Phase 2
Details
Lead Sponsor:
Kawut, Steven, MD
Collaborators:
Columbia University National Heart, Lung, and Blood Institute (NHLBI)