A Study of Chinese Medicine Treating Depression

• Status: Unknown status
• Trial end date: 2020-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Chinese Medicine syndrome differentiation has been a prevalent therapy in China for thousands of years. It is based on patients' symptoms, pulse, tongue and coating on the tongue. Therefore, the syndrome of patients and corresponding Traditional Chinese Medicine (TCM) may vary.

This multicenter prospective cohort studies the efficiency and safety of TCM compared with antidepressants. A total number of 4600 cases with primary depression are expected to be collected and divided into 3 cohorts based on the patients' requirement and choices. Patients in one group will receive TCM, and patients in the other two groups will respectively receive antidepressants only and integrated treatment of TCM and antidepressants. This study has 2 phases: treating period and the follow-up.

The main purpose of this long-term study is to evaluate the efficiency of TCM compared with antidepressants in reducing relapse and suicide rate, changing lifestyle, improving patient compliance as well as the safety.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Third Affiliated Hospital of Beijing University of Chinese Medicine
• Collaborators: Beijing HuiLongGuan Hospital; Capital Medical University; First Affiliated Hospital of Heilongjiang Chinese Medicine University; Guang'anmen Hospital of China Academy of Chinese Medical Sciences; Shandong University of Traditional Chinese Medicine; The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine; The First Affiliated Hospital of Henan University of Traditional Chinese Medicine; Wu Xi Hospital of Traditional Chinese Medicine; Xiamen Hospital of Traditional Chinese Medicine
• Treatments: Antidepressive Agents

Criteria

Inclusion Criteria:

Subjects meeting all of the following criteria can be included in this study:

• Clinical diagnosis of depression

• The scores of Hamilton Depression scale ( HAMD )≥18

• With stable vital signs, conscious mind and acceptable communication ability

• Can use the mobile phone to do self-evaluation

• Male or female patients between 18 and 65 years old

• Signing the informed consent and agreeing to participate in this study

Exclusion Criteria:

Subjects meeting anyone of the following criteria will be excluded from this study:

• Depression caused by other diseases

• Unstable vital signs

• Severe aphasia and agnosia causing disability to communicate

• Alcoholism and other substance dependence

• Diagnosis of other mental disorders except depression

• Serious hepatic or renal insufficiency

• Pregnancy or lactation