A Study of Combination Therapy in Children With ADHD
Status:
Completed
Trial end date:
2015-03-01
Target enrollment:
Participant gender:
Summary
Lack of appetite and weight loss are a common side effect of ADHD therapy with amphetamines
such as methylphenidate. Lack of sufficient food intake has been shown to have negative
effects on weight and height as well as learning and memory.
There is no current treatment to prevent this loss of appetite except discontinuation or
reduction of the methylphenidate. Discontinuation or reduction of the drug can cause the
return of ADHD symptoms.
The purpose of this study is to compare the effects, good and/or bad, of two doses of a drug,
cyproheptadine, vs placebo to find out if cyproheptadine prevents the appetite suppression
associated with methylphenidate.