Overview
A Study of Continuous Subcutaneous Insulin Infusion (CSII) Pump Function in Subjects With Type 1 Diabetes With Recombinant Human Hyaluronidase (rHuPH20)
Status:
Completed
Completed
Trial end date:
2014-02-27
2014-02-27
Target enrollment:
0
0
Participant gender:
All
All
Summary
The goal of this study is to determine if Hylenex recombinant leads to changes in the insulin time-action profiles and glucose responses when preadministered in the setting of continuous subcutaneous insulin infusion (CSII) compared to CSII without Hylenex recombinant (sham injection).Phase:
Phase 4Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Halozyme TherapeuticsTreatments:
Insulin
Insulin, Globin Zinc
Insulin, Short-Acting
Criteria
Inclusion Criteria:1. Male or female participants between the ages 18 and 65 years, inclusive.
2. Females of child-bearing potential must agree to use a standard and effective means of
birth control for the duration of the study. Adequate contraceptive measures include
oral or injectable contraceptives, sterilization, intra-uterine device (IUD), barrier
methods, or abstinence.
3. Participants with type 1 diabetes mellitus treated with insulin (multiple daily
injections or continuous subcutaneous insulin infusion [CSII]) diagnosed ≥ 12 months
prior to enrollment
4. Body mass index (BMI) 18.0 to 32.0 kilograms per meters squared (kg/m^2)
5. HbA1c (glycated hemoglobin A1c) ≤ 10% based on local laboratory results
6. Fasting C-peptide < 0.6 nanograms per milliliter (ng/mL)
7. Current treatment with insulin <1.2 Units per kg per day (U/kg/day)
8. Participant should be in good general health based on medical history and physical
examination, without medical conditions that might prevent the completion of study
drug injections and assessments required in this protocol
Exclusion Criteria:
1. Inability to comply with study requirements as judged by the Investigator
2. Known or suspected allergy to any component of any of the study drugs in this trial
3. A participant who has proliferative retinopathy or maculopathy, severe gastroparesis,
and/or severe neuropathy, in particular autonomic neuropathy, as judged by the
Investigator
4. As judged by the Investigator, clinically significant active disease of the
gastrointestinal, cardiovascular (including a history of arrhythmia or conduction
delays on electrocardiogram), hepatic, neurological, renal, genitourinary, or
hematological systems
5. As judged by the Investigator, uncontrolled hypertension (diastolic blood pressure ≥
100 millimeters of mercury [mmHg] and/or systolic blood pressure ≥ 160 mmHg after 5
minutes in the supine position)
6. History of any illness or disease that in the opinion of the Investigator might
confound the results of the trial or pose additional risk in administering the study
drugs to the participant
7. As judged by the Investigator, clinically significant findings in routine laboratory
data. Anemia with hemoglobin less than lower limits of normal at screening is
specifically exclusionary
8. Use of drugs that may interfere with the interpretation of trial results or are known
to cause clinically relevant interference with insulin action, glucose utilization, or
recovery from hypoglycemia, or drugs not permitted according to Hylenex recombinant
package insert
9. Recurrent major hypoglycemia or hypoglycemic unawareness, as judged by the
Investigator
10. Current addiction to alcohol or substances of abuse as determined by the Investigator
11. Blood donation (> 500 mL) within the previous 8 weeks (56 days) prior to Day -1 of
Treatment Period 1
12. Pregnancy, breast-feeding, the intention of becoming pregnant, or not using adequate
contraceptive measures (adequate contraceptive measures consist of sterilization, IUD,
oral or injectable contraceptives, or barrier methods)
13. Mental incapacity, unwillingness, or language barriers precluding adequate
understanding or cooperation in this study
14. Participation in any other clinical trial and receipt of any investigational drug
within 4 weeks of Day -1 of Treatment Period 1
15. Any condition (intrinsic or extrinsic) that in the judgment of the Investigator will
interfere with trial participation or evaluation of data
16. Positive for human immunodeficiency virus (HIV), Hepatitis C or Hepatitis B
17. Tobacco and nicotine use within 3 months prior to Day 1 of Treatment Period 1 or use
during the study