A Study of Dideoxycytidine in HIV-Infected Patients

• Status: Completed
• Trial end date: 1988-12-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine how much of a dose is absorbed by the body when zalcitabine ( dideoxycytidine; ddC ) is given orally and how long the drug stays in the body after absorption or intravenous (IV) administration.

Laboratory tests have shown that ddC is effective in stopping the growth of the HIV in test tubes. The study will reveal the pharmacokinetic (blood levels) properties of this new drug and how long the drug remains in the body at each of six doses. This should be useful background information and should allow a simple and efficient comparative study of any new oral formulation, such as a tablet or capsule, since dose-related problems will already be known.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
• Treatments: Zalcitabine

Criteria

Inclusion Criteria

Prior Medication:

Allowed:

• Oral nonabsorbable antifungal agents.

Exclusion Criteria

• Active drug or alcohol abuse.

Co-existing Condition:

• Patients with fever > 102 degrees F at study entry will be excluded.

• Patients with fever > 102 degrees F at study entry will be excluded.

Prior Medication: Excluded:

• Chronic systemic medications.

• Any other experimental drug within 2 weeks of study entry.

• Drugs with known nephrotoxic or hepatotoxic effects within 2 weeks of study entry.

• Drugs known to cause neutropenia within 2 weeks of study entry.

• Rifampin or rifampin derivatives, phenytoin, or barbiturates within 2 weeks of study entry.

• Any other medication except oral nonabsorbable antifungal agents within 72 hours of study entry.

All medications, including aspirin, must be approved by investigator. All medications, including aspirin, must be approved by investigator.

Patients must demonstrate the following clinical and laboratory findings:

• AIDS, AIDS related complex (ARC), or persistent generalized lymphadenopathy as defined by the CDC classification.

• No ascites.

• Off all medications except oral antifungal, nonabsorbable agents for 72 hours prior to study entry.