A Study of Different Doses of Atevirdine Mesylate Plus Zidovudine in HIV-Positive Patients

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

To determine the tolerance and antiviral response of two different doses of atevirdine mesylate (U-87201E) in symptomatic HIV-positive patients with CD4 counts of 50-350 cells/mm3, who also take zidovudine (AZT).

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pharmacia and Upjohn
• Treatments: Atevirdine; Zidovudine

Criteria

Inclusion Criteria

Concurrent Medication:

Allowed:

• Primary or secondary prophylaxis for opportunistic infections.

Patients must have:

• HIV infection.

• Symptoms (currently or prior to enrollment) included in Category B or C of CDC classification, although THE FOLLOWING CURRENT ACUTE MEDICAL CONDITIONS ARE NOT ALLOWED:

• Cryptococcosis

• Pneumocystis carinii pneumonia

• Herpes zoster

• Histoplasmosis

• CMV

• Hepatic or renal disease

• Lymphoma.

• CD4 count 50 - 350 cells/mm3 within 14 days prior to study entry.

• Ongoing therapy with AZT at 500 - 600 mg total daily dose for at least 3 months prior to study entry.

• Consent of parent, guardian, or person with power of attorney if less than 18 years of age.

Exclusion Criteria

Co-existing Condition:

Patients with the following conditions are excluded:

• Intolerance to AZT.

• Current diagnosis of malignancy for which systemic therapy will be required during the study.

Concurrent Medication:

Excluded:

• Any other investigational drugs.

Prior Medication:

Excluded:

• Cytotoxic chemotherapy within 1 month prior to study entry.

• Prior U-87201E or any other non-nucleoside antiretroviral medications, including but not limited to nevirapine, TIBO R-82150 or TIBO R-82913, L-697639 or L-696229, U-90152S, or any protease inhibitors.

• Antiretroviral agents other than AZT within 3 months prior to study entry.

Required:

• AZT for at least 3 months prior to study entry. Present use of excessive alcohol or illicit drugs.