A Study of Fibrin Sealant Plus Silver Microparticles to Prevent Incisional Hernias Following Abdominal Surgery
Status:
Withdrawn
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
Incisional hernias are a frequent consequence of abdominal surgery. Current clinical efforts
are primarily focused on improving repair materials and surgical techniques to correct these
hernias instead of the optimal solution: prevention.
A product called MYOSEAL is currently being developed to prevent hernia formation after
abdominal surgery by using fibrin tissue sealant and silver particles to prophylactically
enhance the early wound healing of myofascial incisions. The purpose of this phase 1 study is
to examine the safety of applying MYOSEAL immediately after abdominal wall suture closure in
patients undergoing abdominal surgery. The investigators expect that applying this product to
sutured myofascial incisions will increase collagen formation in the wound and thus prevent
the formation of incisional hernias.