A Study of Fresolimumab in Patients With Steroid-Resistant Primary Focal Segmental Glomerulosclerosis (FSGS)

• Status: Completed
• Trial end date: 2014-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary objectives of this trial are as follows:

• to compare the achievement of a partial remission (PR) or complete remission (CR) in urinary protein: creatinine ratio (Up/c ratio) in patients treated with fresolimumab versus placebo

• to compare the safety profile of patients treated with fresolimumab versus placebo

The secondary objectives are as follows:

• To compare the reduction in proteinuria in patients treated with fresolimumab versus placebo

• To evaluate fresolimumab dose-dependent reduction in proteinuria

• To compare the change in renal function (estimated glomerular filtration rate [eGFR]) in patients treated with fresolimumab versus placebo

• To evaluate the multiple-dose pharmacokinetics of fresolimumab

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Genzyme, a Sanofi Company
• Treatments: Antibodies, Monoclonal

Criteria

Inclusion Criteria:

• The patient's renal biopsy is consistent with the diagnosis of primary Focal Segmental Glomerulosclerosis (FSGS) including all histological subtypes.

• The patient has an eGFR ≥ 30 mL/min/1.73 m2

• The patient has a urinary total protein:creatinine ratio ≥ 3 mg protein/mg creatinine

• In the opinion of the Investigator, the patient has steroid-resistant FSGS. The patient must have been treated for FSGS with a course of high-dose steroid therapy for a minimum of 4 weeks

• The patient has been treated with an ACEi (angiotensin converting enzyme inhibitor) and/or ARB (angiotensin receptor blocker) at a stable dose for a minimum of 4 weeks prior to Visit 2 (treatment start)

Exclusion Criteria:

• The patient has FSGS which in the Investigator's opinion is secondary to another condition

• The patient has been taking prednisone at a dose > 10 mg/day (or equivalent dose of an alternative glucocorticoid) within 4 weeks prior to Visit 1 (Screening Visit).

• The patient has received any other systemically administered immunosuppressive drugs (other than glucocorticoids) within 8 weeks prior to Visit 1.

• The patient has received rituximab within 6 months prior to Visit 1.

• The patient has a history of organ transplantation.