A Study of KC1036 in Patients With Advanced Thymic Tumors

• Status: Not yet recruiting
• Trial end date: 2026-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a single arm，open-label, multicentric, phase II study to evaluate the efficacy and safety of KC1036 in patients with advanced recurrent or metastatic thymoma or thymic carcinoma.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beijing Konruns Pharmaceutical Co., Ltd.

Criteria

Inclusion Criteria:

• Patients with thymoma or thymic carcinoma confirmed by cytologically or histologically (WHO Classification of Thoracic Tumors 5th ed), including all pathological subtypes;

• Patients with advanced recurrent, unresectable and/or metastatic thymic tumor as defined by the Masaoka-Koga stage;

• Subsequent relapse of disease following first-line systemic chemotherapy;

• Patients with at least one measurable lesion as defined by RECIST V1.1; Measurable lesions located within the radiation field of previous radiotherapy or after local treatment can also be selected as target lesions if progression is confirmed.

• Eastern Cooperative Oncology Group performance status score of 0 or 1;

• Life expectancy > 12 weeks;

• Adequate organ and marrow function;

• Patients should participate in the study voluntarily and sign informed consent.

Exclusion Criteria:

• Patients with thymus neuroendocrine tumors;

• Any patient who is known to have central nervous system (CNS) metastasis or imaging shows a risk of CNS metastasis;

• Previous (within the last 5 years) or current malignancies at other sites;

• Gastrointestinal abnormalities;

• Cardiovascular and cerebrovascular diseases;

• Patients who have previous treatment with small molecule VEGFR-TKI (except patients whose treatment cycle is less than 2 weeks due to intolerance or other reasons); Patients who have previous treatment with PD-1 / PD-L1 antibody combined with small molecule VEGFR-TKI;

• Involved in other clinical trials within 4 weeks before enrollment; Prior anti-tumor therapies with chemotherapy, cytotherapy, immunotherapy, operation (Interventional therapy excepted) within 4 weeks 4 weeks before enrollment; Prior radiotherapy (palliative radiotherapy excepted) within 2 weeks; Prior small-molecule targeted therapy within 2 weeks or 5 half-lives.

• Presence of unresolved toxicities from prior anti-tumor therapy, defined as having not resolved to NCI CTCAE V5.0 grade 0 or 1 with the exception of alopecia;

• Skin wound, surgical site, wound site, mucous membrane severe ulcer or fracture comfirmed as having not recovered;

• Uncontrolled mass pleural effusion, ascites, and pericardial effusion;

• Active autoimmune diseases: Myasthenia gravis, pure red cell aplastic anemia, systemic lupus erythematosus, inflammatory bowel disease, etc;

• Need immunosuppressive agents or hormone therapy for immunosuppression, , and still need immunosuppressive therapy within 2 weeks before enrollment;

• Active bacterial, viral or fungal infection; Fever of unknown cause (> 38.5℃) occurred within 2 weeks before enrollment;

• Patients who are positive for both Hepatitis B surface antigen (HBsAg) and hepatitis B virus deoxyribonucleic acid (HBV-DNA) quantification results; Patients who are positive for both hepatitis C virus antibody (HCAB) and hepatitis C virusribonucleic acid (HCV-RNA) quantification results; Patients who are positive for human immunodeficiency virus (HIV);

• Pregnant or lactating women;

• Patients who do not take contraception during the study period and within 6 months after the study;

• Patients with insufficient compliance as evaluated by investigator;

• The investigator believes that it is not suitable to patient in this clinical trial.