A Study of LY3415244 in Participants With Advanced Solid Tumors

• Status: Terminated
• Trial end date: 2019-10-09
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study is to evaluate the safety of LY3415244, a PD-L1/TIM-3 bispecific antibody, administered as monotherapy to participants with advanced solid tumors.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Eli Lilly and Company

Criteria

Inclusion Criteria:

• For Phase 1a/b, histologic or cytologic confirmation of advanced solid tumor.

• For Phase 1a/b, biopsy of tumor samples are required. Newly obtained core or excisional biopsy of a tumor lesion prior to study enrollment and undergo a biopsy procedure during the study.

• Phase 1a, prior anti-PD-1 or anti-PD-L1 therapy or other immunotherapy is allowed.

• Phase 1b, prior anti-PD-1 or anti-PD-L1 therapy is required where anti-PD-1 or anti-PD-L1 is standard of care in respective tumor types if the following criteria are met:

• Must not have experienced a toxicity that led to permanent discontinuation of prior immunotherapy

• Must have completely recovered to baseline level prior to screening from any adverse events (AEs) that occurred from receiving prior immunotherapy

• Must not have experienced a Grade ≥3 immune-related AE or immune related neurologic or ocular AE, pneumonitis or cardiomyopathy of any grade while receiving prior immunotherapy

• Must not have required immunosuppressive agent, other than corticosteroids for the management of an adverse event and not currently require maintenance doses of >10 milligrams (mg) prednisone (or equivalent) per day

• Must have at least 1 measurable lesion as defined by the Response Evaluation Criteria in Solid Tumors (RECIST 1.1).

• Have adequate organ function.

• Have an estimated life expectancy ≥12 weeks, in the judgement of the investigator.

Exclusion Criteria:

• Have symptomatic central nervous system (CNS) malignancy or metastasis not requiring concurrent treatment, including but not limited to surgery, radiation, corticosteroids and/or anticonvulsants to treat CNS metastases, and their disease is asymptomatic and radiographically stable for at least 30 days.

• Have received a live vaccine within 30 days before the first dose of study treatment.

• If female, is pregnant, breastfeeding, or planning to become pregnant.

• Have a history or current evidence of any condition, therapy, or laboratory abnormality that might interfere with the participant's participation.

• Have moderate or severe cardiovascular disease.

• Have a serious concomitant systemic disorder that would compromise the participant's ability to adhere to the protocol, including known infection with human immunodeficiency virus (HIV), active hepatitis B virus (HBV), active hepatitis C virus (HCV), active autoimmune disorders, or prior documented severe autoimmune or inflammatory disorders requiring immunosuppressive treatment.

• Use of escalating or chronic supraphysiologic doses of corticosteroids or immunosuppressive agents (such as, cyclosporine). [Use of topical, ophthalmic, inhaled, and intranasal corticosteroids permitted].

• Bowel obstruction, history or presence of inflammatory enteropathy or extensive intestinal resection.

• Evidence of interstitial lung disease or noninfectious pneumonitis.