Overview

A Study of LY3502970 in Chinese Participants With Obesity or Are Overweight With Weight-related Comorbidities

Status:
Active, not recruiting
Trial end date:
2024-07-01
Target enrollment:
0
Participant gender:
All
Summary
The main purpose of this study is to learn about the safety and tolerability of LY3502970 when given to Chinese participants with obesity or overweight with weight-related comorbidities. Blood tests will be performed to investigate how the body processes the study drug and how the study drug affects the body. Each enrolled participant will receive LY3502970, or placebo given orally. For each participant, the study will last about approximately 22- and 30-weeks for both cohort 1 and 2, respectively including screening period.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Eli Lilly and Company
Criteria
Inclusion Criteria:

- Are native Chinese males or females

- Have had a stable body weight for the 3 months prior to randomization (less than 5%
body weight change) and body mass index of ≥ 30.0 kilograms per square meter (kg/m²)
or between 27.0 up to 30.0 kg/m² with at least 1 of the following weight-related
comorbidities including Hypertension, Dyslipidemia, Cardiovascular disease,
Obstructive sleep apnea

Exclusion Criteria:

- Have any prior diagnosis of type 1 diabetes mellitus (T1DM) or type 2 diabetes
mellitus (T2DM), or rare forms of diabetes mellitus

- Have used or intend to use any prescription or over-the-counter medications or
traditional Chinese treatments within 3 months prior to screening, exception of
medications for the treatment of concurrent medical conditions with a stable dose

- Have known allergies to GLP-1RAs, LY3502970, related compounds, any components of the
formulation, or have a history of significant atopy

- Are overweight or have obesity induced by other endocrinological disorders, diagnosed
monogenetic, or syndromic forms of obesity

- Have or plan to have a surgical, endoscopic or device-based treatment for obesity

- Have a history or presence of psychiatric disorder, a moderately severe or severe
depression status, or a significantly risk for suicide

- Have a history of acute or chronic pancreatitis

- Have a known self or family history of multiple endocrine neoplasia type 2A or type
2B, thyroid C-cell hyperplasia, or medullary thyroid carcinoma

- Have other acute, chronic, or uncontrolled medical conditions, vital organ failure or
abnormal laboratory value in the judgment of the investigator would make the
participant inappropriate for entry into this study