A Study of Magnesium and Bladder Spasms Following Ambulatory Urologic Procedures

• Status: Not yet recruiting
• Trial end date: 2024-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This research is being done to find out whether intravenous magnesium is effective in the treatment of bladder spasms after urologic surgery.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic

Criteria

Inclusion Criteria:

• Be undergoing a bladder invasive procedure with or without planned urinary catheter on Mayo Clinic Gonda 7 Outpatient Procedure Center.

Exclusion Criteria:

• Are unable to grant informed consent or comply with study procedure.

• Allergy or known sensitivity to magnesium or Renacidin.

• Expected or high risk of bladder extravasation.

• Ongoing atrial fibrillation prior to surgery.

• Are undergoing emergency surgery.

• Are pregnant.

• Known hypermagnesemia.

• Patients with neuromuscular weakness (e.g., Myasthenia gravis) due to magnesium's muscle weakening effect.

• Patients with myocardial compromise or cardiac conduction defects because of magnesium's anti-inotropic effects.

• Patients with renal insufficiency, glomerular filtration rate less than 30, since Magnesium is eliminated by the kidneys resulting in exaggerated rise in serum magnesium.

• Patients with concomitant use of a calcium channel blocker since magnesium sulfate could act synergistically to suppress muscular contractility.