Overview

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer

Status:
Active, not recruiting
Trial end date:
2027-02-19
Target enrollment:
0
Participant gender:
Male
Summary
The purpose of this study is to evaluate the effectiveness of niraparib in combination with abiraterone acetate plus prednisone (AAP) compared to AAP and placebo.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Janssen Research & Development, LLC
Treatments:
Abiraterone Acetate
Niraparib
Prednisone
Criteria
Inclusion Criteria:

- HRR gene alteration (as identified by the sponsor's required assays) as follows:

1. Cohort 1: positive for HRR gene alteration

2. Cohort 2: not positive for DRD (that is, HRR gene alteration)

3. Cohort 3: eligible by HRR status

- Metastatic disease documented by positive bone scan or metastatic lesions on computed
tomography (CT) or magnetic resonance imaging (MRI)

- Metastatic prostate cancer in the setting of castrate levels of testosterone less than
or equal to (<=) 50 nanogram per deciliter (ng/dL) on a gonadotropin releasing hormone
analog (GnRHa) or bilateral orchiectomy

- Able to continue GnRHa during the study if not surgically castrate

- Score of <= 3 on the brief pain inventory-short form (BPI-SF) question number 3 (worst
pain in last 24 hours)

Exclusion Criteria:

- Prior treatment with a poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP)
inhibitor

- Systemic therapy (that is, novel second-generation AR-targeted therapy such as
enzalutamide, apalutamide, or darolutamide; taxane-based chemotherapy, or more than 4
months of abiraterone acetate plus prednisone [AAP] prior to randomization) in the
metastatic castration-resistant prostate cancer (mCRPC) setting; or AAP outside of the
mCRPC setting

- Symptomatic brain metastases

- History or current diagnosis of myelodysplastic syndrome (MDS)/acute myeloid leukemia
(AML)

- Other prior malignancy (exceptions: adequately treated basal cell or squamous cell
skin cancer, superficial bladder cancer, or any other cancer in situ currently in
complete remission) <= 2 years prior to randomization, or malignancy that currently
requires active systemic therapy