Overview

A Study of Oral Minoxidil to Treat Hair Loss in Children, Teens, and Young Adults Who Are Cancer Survivors

Status:
Recruiting
Trial end date:
2026-03-01
Target enrollment:
0
Participant gender:
All
Summary
This study will test whether minoxidil taken by mouth (oral minoxidil) can improve hair loss caused by cancer treatment in children and young adults. In addition, the researchers will test the safety of oral minoxidil, and see if the study drug causes few or mild side effects in participants. Other purposes of this study include looking at whether participants are able to follow their study drug dosing schedules, and how oral minoxidil affects participants' quality of life.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Memorial Sloan Kettering Cancer Center
Treatments:
Minoxidil
Criteria
Inclusion Criteria:

- Patients must have been diagnosed with cancer before the age of 17.

- They must have completed either systemic or radiation therapy (cytotoxic chemotherapy
and external beam radiation therapy) for their cancer at least 1 year prior to study
entry.

- They must be between 6-18 years old at the time of enrollment.

- They must have a clinical diagnosis of persistent or late alopecia for >6 months and
that is definitely, probably, or possibly related to prior chemotherapy and/or
radiation.

Exclusion Criteria:

- Had a history of alopecia prior to systemic or radiation therapy for cancer, or has
alopecia unrelated to cancer treatment.

- Have scalp disorders that preclude the evaluation of alopecia, such as psoriasis

- Has a known hypersensitivity to minoxidil

- Concurrent use of other therapies for alopecia

- Concurrent active anticancer therapies (cytotoxic, targeted, endocrine, immunologic)

- History of chronic cutaneous GvHD

- History of orthostatic or symptomatic hypotension, syncope related to hypotension;
systolic less than or equal than 100 (for adults) and 90 (for children) at screening.

- Pregnancy.

- Cardiovascular disease that in the opinion of the cardiologist makes the patient
unsuitable for therapy

- Blood pressure less than the 5th percentile or less than 90/50 mmHg for children 10
years or older