Overview

A Study of PRS-344/S095012 (PD-L1x4-1BB Bispecific Antibody-Anticalin Fusion) in Patients With Solid Tumors

Status:
Recruiting
Trial end date:
2024-11-15
Target enrollment:
0
Participant gender:
All
Summary
This is a first-in-human (FIH), phase 1/2, multi center, open-label, dose escalation and cohort expansion study designed to determine the safety and tolerability of PRS-344/S095012 in patients with advanced and/or metastatic solid tumors.
Phase:
Phase 1/Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Pieris Pharmaceuticals, Inc.
Collaborator:
Institut de Recherches Internationales Servier (I.R.I.S.)
Criteria
Inclusion Criteria:

1. Age ≥18 years on the day the consent is signed.

2. Patients with histologically confirmed diagnosis of unresectable, locally advanced or
metastatic solid tumor for which standard treatment options are not available, no
longer effective, or not tolerated.

3. Patient should have a documented disease progression on prior therapy before entry
into this study.

4. Patients must have at least one measurable target lesion as per RECIST 1.1.

5. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

6. Patient with no available archived material must have one or more tumor lesions
amenable to biopsy.

7. Adequate organ function as assessed by laboratory tests within 72 hours prior to the
start of treatment.

8. A female patient must use a highly effective method of birth control during study
treatment and until 120 days after last dose of study treatment.

Dose Expansion

9. Patients who have had prior checkpoint inhibitor (CPI) treatment in the past 6 months
must have documented confirmed radiographic progression from it prior to study entry.

10. Patients must have received and progressed on only one prior regimen in the metastatic
setting comprising an PD-(L)1 plus chemotherapy.

Exclusion Criteria:

1. Patients with previously treated brain metastases may participate provided they are
radiologically stable, clinically asymptomatic and are off immunosuppressive therapies
for at least 4 weeks. Low dose of steroid <10 mg/day prednisone or equivalent) is
allowed.

2. Patients who have received prior:

1. Small molecule inhibitors, and/or other similar investigational agent: ≤ 2 weeks
or 5 half-lives, whichever is shorter.

2. Chemotherapy, other monoclonal antibodies, antibody-drug conjugates, or other
similar experimental therapies: ≤3 weeks or 5 half-lives, whichever is shorter.

3. Radioimmunoconjugates or other similar experimental therapies ≤6 weeks or 5
half-lives, whichever is shorter.

3. Patients who have received 4-1BB agonists in the past.

4. Patients who had a major surgery within 4 weeks prior to first administration of IMP.

Dose Expansion:

5. Patient who received therapy with an irinotecan containing regimen.

6. Patient must not be on warfarin, strong cytochrome P450 (CYP) 3A4 inducers, strong
CYP3A4 inhibitors, or strong UGT1A1 inhibitors.