A Study of Plurogel® Compared to Standard Topical Dressing in Burn Injuries
Status:
Not yet recruiting
Trial end date:
2023-06-01
Target enrollment:
Participant gender:
Summary
Burn injuries can result in long term physical and mental sequelae, not only from the
scarring but also the painful dressings. The standard of care today remains use of antibiotic
topical dressings while awaiting demarcation of the burn depth, with surgical excision and
grafting for deep partial thickness and full thickness areas. Demarcation can be appreciated
on admission for full thickness burns but is often a prolonged process that can last weeks.
The clinical evaluation of the depth of the burn is a complex decision that often is made
more challenging by the presence of the proteinaceous pseudoeschar and the coagulated dermis
itself. Surgical debridement is relatively 'coarse' and by its very nature requires removal
of a thin layer of viable tissue to reach the level that is vascularized enough to support a
skin graft. There has been growing interest in the use of adjuncts to reduce the amount
tissue debrided and potentially reduce the need for surgery itself. Operatively, there have
been some reports that use of hydro-dissection devices (Versajet™) may allow a more
controlled debridement, resulting in less viable tissue being sacrificed. There is also a
growing experience with enzymatic debridement, especially with Bromolein, derived from
Pineapple (NexoBrid®). Neither of these have been shown to definitively improve care in
randomized controlled trials, (RCTs) and there is suggestion that in some settings may
actually cause harm.