A Study of Prevention and Treatment of Postmenopausal Osteoporosis in Chinese Women

• Status: Completed
• Trial end date: 2006-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this trial is to study the efficacy and safety of low dose of estradiol valerate in the prevention and treatment of postmenopausal osteoporosis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Peking Union Medical College
• Treatments: Estradiol; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Estradiol valerate; Medroxyprogesterone; Medroxyprogesterone Acetate; Polyestradiol phosphate

Criteria

Inclusion Criteria:

All patients meet the criteria:

1. Patients with informed consent.

2. Breast Cancer inform possible danger.

3. Physical and mental health.

Menopausal transition meet the criteria:

1. Age between 40 ~ 55 years old.

2. Women with Menopause syndrome or menstrual disorders.

3. The second to fourth lumbar spine bone mineral density to normal.

Early postmenopause meet the criteria:

1. Age between 45 ~ 60 years old.

2. Spontaneous amenorrhea for more than six months and less than 5 years.

3. The second to fourth lumbar spine bone mineral density was between -1 and -2.5 Standard deviation Compared with normal young women.

Exclusion Criteria:

1. Tobacco or alcohol abuser.

2. History of various malignant diseases.

3. Women with Serious chronic diseases, such as liver and kidney dysfunction.

4. Women Suffering from endocrine diseases, such as Thyroid disease, Parathyroid disease,Adrenal disease and Osteomalacia.

5. Women with Long-term application of drugs, such as Antiepileptic drug, Adrenocorticotropic hormone, Diuretics and Heparin.

6. Women had used estrogen or calcitonin in the past 6 months.

7. Women has added higher than the physiological requirements VitD.

8. Who had taken bisphosphonates or sodium fluoride in the past 1 year.

9. Women had been taking Chinese medicines or other unregistered food in past 3 months.

10. Women with one of the following medical history or disease: Thrombophlebitis, estrogen-related thrombosis or thromboembolism, Cerebrovascular accident, with known or suspected estrogen-dependent tumor, undiagnosed vaginal bleeding, Cervical Pap smear graded at 3 or more, Serious uterine disorders, Serious breast disorders, Serious gallbladder disease, Severe hypertension and Hypercholesterolemia

11. Secondary osteoporosis.

12. Participants' lumbar spine anatomy(at least L1~L4) is not suitable to do dual-energy X-ray absorptiometry measured, such as obvious scoliosis, bone injury and Orthopedic surgery Sequelae.

13. Doctor consider inappropriate to participate in because of other diseases.