A Study of R1507 in Combination With Multiple Standard Chemotherapy Treatments in Patients With Advanced Solid Tumors
Status:
Terminated
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
This study will evaluate the safety and tolerability of R1507 in combination with 12 distinct
standard chemotherapy drug regimens and an additional R1507 monotherapy arm in patients with
advanced malignant neoplasms.The 12 regimens will be tested in parallel. There are 3 subsets
of patients who are eligible for the study: untreated, treated and requiring further
treatment, or treated and failed and for whom adding R1507 represents a suitable treatment
for their disease. All regimens will first test doses of R1507 which are less than the
maximally administered dose, and if tolerated, the dose will be escalated in subsequent
patients. The anticipated time on study treatment is until disease progression, and the
target sample size is 100-500 individuals.