A Study of SGN-ALPV in Advanced Solid Tumors

• Status: Not yet recruiting
• Trial end date: 2027-11-30
• Target enrollment: 0
• Participant gender: All

Summary

This study will test the safety of a drug called SGN-ALPV in participants with solid tumors. It will also study the side effects of this drug. A side effect is anything a drug does to your body besides treating your disease.

Participants will have solid tumor cancer that has spread through the body (metastatic) or cannot be removed with surgery (unresectable).

This study will have three parts. Parts A and B of the study will find out how much SGN-ALPV should be given to participants. Part C will use the dose and schedule found in Parts A and B to find out how safe SGN-ALPV is and if it works to treat solid tumor cancers.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seagen Inc.

Criteria

Inclusion Criteria:

• Participants must have one of the following histologically or cytologically confirmed metastatic or unresectable solid tumor types:

• Parts A and B

• Ovarian cancer

• Endometrial cancer

• Non-small cell lung cancer (NSCLC)

• Gastric

• Cervical cancer

• Malignant testicular germ cell tumor (GCT), except for pure teratomas

• Malignant ovarian GCT, except for pure teratomas

• Part C

• High-grade serous ovarian cancer (HGSOC): Participants must have HGSOC which has progressed or relapsed within 6 months after previous platinum containing chemotherapy and received 1 to 3 prior anticancer lines of therapy including at least 1 line of therapy containing bevacizumab or a biosimilar to bevacizumab.

• Endometrial Cancer: Participants must have unresectable locally advance or metastatic endometrial carcinoma and have had at least 1 prior line of therapy.

• NSCLC: Participants must have unresectable locally advanced or metastatic NSCLC and have received platinum-based therapy and a PD-(L)1 inhibitor.

• Gastric cancer: Participants must have unresectable locally advanced or metastatic gastric cancer and have received prior platinum and fluoropyrimidine -based chemotherapy

• Participants enrolled in the following study parts should have an appropriate tumor site and agree to a biopsy

• Disease-specific expansion cohorts, subjects 16 onwards: pretreatment biopsy.

• Biology expansion cohort: pretreatment biopsy, on-treatment biopsy during Cycle 1, and end of treatment biopsy.

• Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1

• Measurable disease per the RECIST v1.1 at baseline

Exclusion Criteria:

• History of another malignancy within 3 years of first dose of study treatment or any evidence of residual disease from a previously diagnosed malignancy. Exceptions are malignancies with a negligible risk of metastasis or death.

• Known active central nervous system metastases.

• Previous receipt of an MMAE-containing agent or an agent targeting ALPP or ALPPL2.

• Pre-existing neuropathy ≥ Grade 2 per National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 5.0