Overview
A Study of Venetoclax in Combination With Chemotherapy to Treat Newly Diagnosed Acute Lymphoblastic Leukemia (ALL)
Status:
Not yet recruiting
Not yet recruiting
Trial end date:
2024-05-01
2024-05-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
The researchers are doing this study to find out whether combining venetoclax with several different standard chemotherapy drugs used to treat acute lymphoblastic leukemia (ALL) in children is safe and effective in adults with newly diagnosed ALL. Participants in this study will be under the age of 60, and they will have T- or B-cell ALL.Phase:
Early Phase 1Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Memorial Sloan Kettering Cancer CenterCollaborator:
Genentech, Inc.Treatments:
VenetoclaxCriteria
Inclusion Criteria:- Adult patients with newly diagnosed Philadelphia chromosome (Ph) negative ALL.
- Patients with T- or B-cell lymphoblastic lymphoma with no bone marrow involvement will
also be eligible for the study.
- Age 18-60
- ECOG performance status of 0-2
- Adequate renal function as demonstrated by a calculated creatinine clearance of ≥ 60
ml/min.
- Adequate hepatic function as demonstrated by a total bilirubin ≤ 2.0 mg/dl (unless
attributable to Gilbert's disease) and an alkaline phosphatase, AST, and ALT ≤ 4 times
the upper limit of normal (unless clinically considered to be related to liver
involvement with leukemia)
- Patients with central nervous system (CNS) involvement by ALL are eligible and may
receive concomitant treatment with radiation therapy and/or intrathecal chemotherapy
in accordance with standard medical practice. For patients with CNS disease,
dexamethasone may be temporarily administered instead of prednisone to reduce CNS
pressure, at the discretion of the treating physician and after discussion with the
MSK PI. Once dexamethasone is no longer needed, prednisone should be given as per
protocol for 28 days.
- Negative serum pregnancy test in women of childbearing potential
Exclusion Criteria:
- CML in lymphoid blast crisis, mature B-cell (i.e. Burkitt's) lymphoma or mixed
phenotype acute leukemia (MPAL)
- Prior treatments for ALL, except any doses of corticosteroids and hydroxyurea or one
dose of vincristine
- Patients who received strong and/or moderate CYP3A inducers within 7 days prior to the
initiation of study treatment
- Unstable angina and/or MI or stroke within 6 months prior to screening, and/or
impaired cardiac function with EF <40% or NYHA class III/IV
- Pregnant or lactating women. Women and men of childbearing age should use effective
contraception while on this study and continue for 1 year after all treatment is
finished.
- Patients with HIV or active hepatitis B or hepatitis C infection are ineligible.
- Patients with concurrent active malignancies as defined by malignancies requiring any
therapy other than expectant observation or hormonal therapy, with the exception of
squamous and basal cell carcinoma of the skin, in situ cervical cancer, adequately
treated stage I/II cancer from which the patient is current in complete remission, or
any other cancer from which the patient has been disease free for five years.