A Study of the Alternative Administration of Ixabepilone and Vinflunine

• Status: Completed
• Trial end date: 2007-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to test how vinflunine interacts with ixabepilone in the human body.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bristol-Myers Squibb
• Treatments: Epothilones; Vinblastine

Criteria

Inclusion Criteria:

• ECOG status of 0-1

Exclusion Criteria:

• Inability to tolerate venous access

• Brain mets

• Severe nerve damage

• ANC <2,000/mm3

• Platelets <100K

• Bilirubin >= 1.5 times the IULN

• ALT/AST >= 2.5 times the IULN

• Creatinine <50 mL/min

• Prior treatment with vinflunine and/or ixabepilone

• Strong use of CYPP450 drugs