A Study of the Effect of Nebivolol to Evaluate Its Vasodilatory Effects in Hypertensive Patients

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The study is designed to compare the effects of nebivolol (10, 20, 40mg/day) with another beta blocker, extended-release metoprolol, at a range of doses. Its purpose is to study the mechanism of action of nebivolol on forearm blood flow, nitric oxide availability and other biomarkers.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Forest Laboratories
• Treatments: Metoprolol; Nebivolol

Criteria

Inclusion Criteria:

• Male or female, ambulatory outpatients 18-79 years old at screening

• Minimum 2-year history of Stage I/II hypertension

• Qualifying blood pressure criteria for study entry and for randomization

• Willing to adhere to the dietary compliance and undergo protocol procedures

• Have a lifestyle that will permit him/her to attend all evaluations, including those conducted on consecutive days

Exclusion Criteria:

• Have any form of secondary hypertension

• Have clinically significant respiratory or cardiovascular disease

• Presence/history of coronary artery disease or peripheral vascular disease

• Have diabetes mellitus, Type I or II

• Have a history of hypersensitivity to nebivolol, metoprolol, or any beta-blocker