A Study of the Effect of Time on Topical Anesthetic Efficacy.

• Status: Unknown status
• Trial end date: 2006-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a study of the effect of time on the effectiveness of topical anesthetics in the mouth. The Null Hypothesis is: Regardless of the time of application over a 10-minute period, there is no difference in the clinical effectiveness of the topical anesthetic 5% lidocaine on (a) the pain of needle stick insertion and (b) the pain of local anaesthetic administration.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Toronto
• Treatments: Anesthetics; Lidocaine

Criteria

Inclusion Criteria:

1. In good health (ASA 1 or ASA 2)

2. Weight between 40-100kg, inclusive.

3. Between ages 18-70, inclusive.

4. Informed consent

Exclusion Criteria:

1. ASA 3 or higher.

2. History of allergy to sulfites, lidocaine or mepivacaine.

3. Taking any analgesic 48hrs before testing, such as an NSAID, opioid, or acetaminophen.

4. Pregnancy.

5. Recent oral trauma.

6. Lack of informed consent.