A Study of the Effect of Vemurafenib on the Pharmacokinetics of Phenprocoumon in Patients With BRAFV600 Mutation-Positive Metastatic Malignancy

• Status: Completed
• Trial end date: 2014-04-01
• Target enrollment: 0
• Participant gender: All

Summary

This open-label, multicenter, parallel study will evaluate the effect of multiple doses of vemurafenib on the pharmacokinetics of a single dose of phenprocoumon in patients with BRAFV600 mutation-positive metastatic malignancies. Patients will be randomized to receive either treatment A: a single oral dose of phenprocoumon 6 mg on Day 1 (Eligible patients will have the option to continue treatment with vemurafenib as part of an extension study (NCT01739764).), or treatment B: vemurafenib 960 mg orally twice daily on Days 1-29 plus a single oral dose of phenprocoumon 6 mg on Day 22 (with the option to receive vemurafenib in the extension study after completion of pharmacokinetic assessments).

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hoffmann-La Roche
• Treatments: Phenprocoumon; Vemurafenib

Criteria

Inclusion Criteria:

• Adult patients, 18-70 years of age

• Patients with either unresectable Stage IIIc or IV BRAFV600 mutation-positive metastatic melanoma or other malignant BRAFV600 mutation-positive tumor type and who have no acceptable standard treatment options

• Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2

• Full recovery from any major surgery or significant traumatic injury at least 14 days prior to the first dose of study treatment

• Adequate hematologic and end organ function

• Female patients of childbearing potential and male patients with female partners of childbearing potential must agree to use 2 effective methods of contraception as defined by protocol during the course of the study and for at least 6 months after completion of study treatment

Exclusion Criteria:

• Prior treatment with vemurafenib or other BRAF inhibitor within 42 days of Day 1

• Prior anti-cancer therapy within 28 days (6 weeks for nitrosureas or mitocyn C, or 14 days for hormonal therapy or kinase inhibitors) before the first dose of study treatment Day 1

• Palliative radiotherapy within 2 weeks prior to first dose of study treatment Day 1

• Experimental therapy within 4 weeks prior to first dose of study treatment Day 1

• History of clinically significant cardiac or pulmonary dysfunction, including current uncontrolled Grade >/=2 hypertension or unstable angina

• Current Grade >/=2 dyspnea or hypoxia or need for oxygen supplementation

• History of myocardial infarction within 6 months prior to first dose of study treatment

• Active central nervous system lesions (i.e. patients with radiographically unstable, symptomatic lesions)

• History of bleeding or coagulation disorders

• Allergy or hypersensitivity to vemurafenib or phenprocoumon formulations

• History of malabsorption or other condition that would interfere with the enteral absorption of study treatment

• History of clinically significant liver disease (including cirrhosis), current alcohol abuse, or active hepatitis B or hepatitis C virus infection

• Human immunodeficiency virus (HIV) infection requiring antiretroviral treatment, or AIDS-related illness

• Pregnant or lactating women