A Study of the Effectiveness of Different Anti-HIV Treatments in HIV-Positive Individuals Who Have Been on a Protease Inhibitor-Containing Drug Regimen for at Least 16 Weeks

• Status: Completed
• Trial end date: 2000-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare different treatments for HIV infection to see which works best to lower HIV levels and to raise the number of CD4 cells (cells of the immune system that fight infection), in HIV-positive individuals who have been on a protease inhibitor-containing drug regimen for at least 16 weeks.

Researchers have found that combination anti-HIV therapy (multiple drugs given together) can help prevent AIDS-related illnesses and help people with AIDS live longer. In this study, the anti-HIV drug efavirenz (EFV) will be tested with 1 or 2 other protease inhibitors (PIs) to see which combination works best to treat HIV infection. EFV has been shown to limit the amount of HIV virus produced by infected cells.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
• Treatments: Efavirenz; HIV Protease Inhibitors; Indinavir; Nelfinavir; Protease Inhibitors; Ritonavir

Criteria

Inclusion Criteria

You may be eligible for this study if you:

• Are HIV-positive.

• Have an HIV RNA count of at least 400 copies/ml.

• Are at least 13 years old (need consent if under 18).

• Have been on antiretroviral treatment (including at least 2 NRTIs) for at least 16 weeks prior to study entry.

• Agree to practice abstinence or to use effective methods of birth control, including a barrier method, during the study.

Exclusion Criteria

You will not be eligible for this study if you:

• Are pregnant or breast-feeding.

• Have active opportunistic (HIV-associated) infections.

• Have taken nelfinavir (NFV) for more than 2 weeks after failing indinavir/ritonavir (IDV/RTV) treatment or have taken IDV/RTV for more than 2 weeks after failing NFV treatment.

• Have used any protease inhibitor other than NFV or IDV/RTV for more than 2 weeks.

• Have used any non-nucleoside reverse transcriptase inhibitor (NNRTI) for more than 1 week.