A Study of the Effects of Minocycline on Cognitive Function After Carotid Endarterectomy
Status:
Withdrawn
Trial end date:
2010-06-01
Target enrollment:
Participant gender:
Summary
The primary aim of this protocol is to investigate a possible new, neuroprotective treatment
to prevent cognitive deficits that occur after carotid endarterectomy. We will investigate
whether a widely used antibiotic agent - minocycline - that has shown neuroprotective effects
in animal models of neurological diseases - can reduce the cognitive deficits associated with
the surgical procedure of carotid endarterectomy (CEA). Because these cognitive deficits are
believed to be a result of small strokes (due to emboli and/or hypoperfusion), this study
will provide preliminary data on the use of this drug as a neuroprotective agent in stroke -
a leading cause of disability.
(1) The first aim of this study is to examine whether 5 doses of minocycline administered 36
hrs before and 1 dose 12 hrs after the surgical procedure in patients undergoing CEA are
effective to reduce the cognitive deficits associated with this procedure as compared with
placebo.
a. The null hypothesis is that there is no difference in cognitive performance changes after
CEA between the patients that receive placebo or minocycline.