A Study of the Effects of Sitagliptin (MK0431) and Metformin on Incretin Hormone Concentrations (0431-050)(COMPLETED)

• Status: Completed
• Trial end date: 2006-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will determine the effect of concomitant administration of sitagliptin and metformin on post-meal incretin hormone concentrations in healthy adults.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Merck Sharp & Dohme Corp.
• Treatments: Gastric Inhibitory Polypeptide; Hormones; Incretins; Metformin; Sitagliptin Phosphate

Criteria

Inclusion Criteria:

• Subject is in good health

• Subject has been a nonsmoker for at least 6 months

• Subject is willing to avoid strenuous activity from the screening visit until the end of the study

• Subject agrees not to consume grapefruit products during the study and to avoid all fruit juices 24 hours before and after study drug administration

Exclusion Criteria:

• Any history of stroke or neurological disorder

• Subject has a history of cardiovascular, blood, endocrine or liver diseases

• Subject has a history of cancer