A Study of the GSK MEK Inhibitor GSK1120212 and Everolimus in Cancer Subjects
Status:
Completed
Trial end date:
2011-11-08
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine the recommended dose and regimen for the orally
administered MEK inhibitor GSK1120212 dosed in combination with everolimus in subjects with
solid tumors. The escalation part of the study will determine the MTD. The combination will
be further explored in the expansion part in subjects with metastatic pancreatic cancer. In
addition, subjects with KRAS mutant non-small cell lung cancer will be enrolled.