A Study of the Relationship Between Disulfiram and Cocaine Self-administration.
Status:
Terminated
Trial end date:
2016-06-01
Target enrollment:
Participant gender:
Summary
The problem of cocaine dependence remains a major medical, social, and legal concern. Several
studies have suggested that disulfiram may be beneficial for the treatment of cocaine
dependence. A common assumption has been that disulfiram treatment, by increasing DA
availability, enhances the aversive aspects of stimulants. This study aims to measure plasma
activity in those with the C/C DBH genotype, which is associated with higher DBH activity
subsequently making the disulfiram treatment more effective, as well as determine the effects
of treatment with disulfiram on cocaine self-administration using a human laboratory model of
cocaine self-administration.