A Study of the Rules for Insulin Dosing in Patients Using Multiple Daily Injections

• Status: Unknown status
• Trial end date: 2010-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will be conducted in subjects with Type 1 diabetes mellitus on multiple daily insulin injections to determine the correct insulin dosing formulas. Subjects will be evaluated using continuous glucose monitoring.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Diabetes Care Center
• Treatments: Insulin; Insulin Glargine; Insulin Lispro; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• Age: >17 years

• Type 1 diabetes

• Diabetes duration > 3 months

• On treatment with multiple daily injections either one or more basal insulin injections each day for 6 weeks

• HbA1c <9.0%

• Stable HbA1c in the proceeding 3 months (i.e., change <1%)

• Demonstrated adherence to visits and instructions

• Attend a class in meal carbohydrate content estimation or have demonstrated knowledge of carbohydrate counting

Exclusion Criteria:

• Major stress event during or for 6 weeks before the evaluation

• Taking a medication that can alter insulin sensitivity

• Within one week of menses

• Unstable eating or activity pattern

• Pregnancy

• Weight gain of > 1.5 kg during the preceding 3 months

• Serum creatinine of >1.5 mg/dl

• Active liver disease

• Evidence of autonomic neuropathy, especially gastroparesis

• Any antidiabetic medication other than insulin

• Treatment with continuous subcutaneous insulin infusion