Overview
A Study on The Effect of Multiple Dose Carbamazepine on Single Dose Pharmacokinetics of RO4917838 in Healthy Volunteers
Status:
Completed
Completed
Trial end date:
2011-07-01
2011-07-01
Target enrollment:
0
0
Participant gender:
Male
Male
Summary
This open-label, fixed sequence, two-period study will assess the effect of multiple dose carbamazepine on the single dose pharmacokinetics of RO4917838. Subjects will receive a single oral dose of RO4917838 on Day 1 of the 12-day study period 1 and, after a washout of 3-6 weeks, in study period 2 carbamazepine orally daily on Days 1-24 with a single oral dose of RO4917838 on Day 16.Phase:
Phase 1Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Hoffmann-La RocheTreatments:
Carbamazepine
Criteria
Inclusion Criteria:- Adult healthy male volunteers, 18-65 years of age inclusive
- Body mass index (BMI) 18-30 kg/m2 inclusive
Exclusion Criteria:
- History or presence of any disorder or condition that would render the subject
unsuitable for the study, place the subject at undue risk or interfere with the
ability of the subject to complete the study in the opinion of the investigator
- History of any significant cardiovascular, hepatic, renal, respiratory,
gastrointestinal, endocrine, immunologic, allergic, dermatologic, hematologic,
neurologic or psychiatric disease, or cancer
- Any confirmed significant allergic reactions against any drug, or multiple allergies
in the judgment of the investigator
- Native Asians or subjects with Asian racial origin