A Study on the Biobehavioral Mechanisms of Baclofen and Alcohol Drinking

• Status: Completed
• Trial end date: 2010-05-01
• Target enrollment: 0
• Participant gender: All

Summary

This pilot trial has the goal to demonstrate the feasibility of a study to test the effects of baclofen in a laboratory experiment using cue-reactivity and alcohol-self administration paradigms in non-treatment seeking alcohol-dependent subjects.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Brown University
• Treatments: Baclofen; Cyproheptadine; Ethanol

Criteria

Inclusion Criteria:

• must be male or female between 21 and 65 years old (inclusive).

• participants must meet criteria for current Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision (DSM-IV-TR) diagnosis of alcohol dependence, supported by the Structured Clinical Interview for DSM-IV-TR Axis I Disorders Patient Edition (SCID-I/P).

• participants must meet criteria for heavy drinking, defined as averaging ≥4 drinks/day for women and ≥5 drinks/day for men during a consecutive 30-day period within the 90 days prior to baseline evaluation (see: Anton et al, 2006). The gender-specific baseline was chosen as it represents heavy drinking that exceeds empirically based levels of moderate alcohol use that result in alcohol-related problems for women who consume ≥4 drinks/day, and men who consume ≥5 drinks/day (Sanchez-Craig et al, 1995).

• participants must be in good health as confirmed by medical history, physical examination, ECG, lab tests.

• females must be postmenopausal for at least one year, surgically sterile, or practicing an effective method of birth control before entry and throughout the study; have a negative urine pregnancy test at each visit.

• participants must be willing to take oral medication and adhere to the study procedures.

Exclusion criteria:

• individuals expressing interest in treatment for alcoholism.

• pregnancy or breast feeding women or not using an adequate form of birth control

• positive urine drug screen at baseline for any illegal substance (a urine drug screen may be repeated once during the screening period).

• individuals diagnosed with a current substance dependence diagnosis, other than alcohol or nicotine.

• meet DSM-IV Axis I criteria for a lifetime diagnosis of schizophrenia, bipolar disorder, or other psychoses.

• an active illness within the past 6 months of Visit 1 that meet the DSM-IV criteria for a diagnosis of Major Depressive Disorder (MDD) or Anxiety Disorder. Subjects with a history of suicide will be excluded.

• clinically significant medical abnormalities (i.e., unstable hypertension, ECG, bilirubin > 150% of the upper normal limit, ALT or AST elevations >300% the upper normal limit, creatinine clearance ≤ 60 dl/min).

• current use of psychotropic medications that cannot be discontinued that may have an effect on alcohol consumption or that may interact with baclofen or cyproheptadine.

• medical contraindications for use of baclofen or cyproheptadine.

• a history of adverse reaction or hypersensitivity to baclofen or cyproheptadine.

• individuals with a reasonable expectation of being institutionalized during the course of the trial.

• participants who have significant alcohol withdrawal symptoms, defined as a Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar) >10.

• history of seizures (e.g. epilepsy).

• subjects who have participated in any behavioral and/or pharmacological study within the past 90 days.