A Study on the Effect of Chemotherapy Combined With Anti-HIV Drugs in HIV-Positive Patients
Status:
Completed
Trial end date:
2001-10-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine the safety of anti-HIV drugs combined with low-dose
chemotherapy (consisting of cyclophosphamide [CTX]) in HIV-positive patients. This study
examines whether this combination therapy can reduce the number of HIV-infected cells hidden
in the lymph nodes and blood.
Current anti-HIV drug treatments can greatly reduce the levels of HIV in the human body.
However, HIV can hide in certain immune cells and escape the drugs' effects. Chemotherapy
using CTX destroys these immune cells. When used with standard anti-HIV drug treatments, CTX
may be able to speed up the elimination of HIV-infected cells.
Phase:
Phase 1
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)