A Study on the Effects of Midazolam on Delirium After Sevoflurane Anesthesia in Pediatric Strabismus Surgery

• Status: Completed
• Trial end date: 2012-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Sevoflurane with its rapid induction and emergence, hemodynamic stability, and nonirritating airway properties, has acquired widespread acceptance in children. However, sevoflurane has been reported to be associated with emergence agitation in children, with a reported incidence of up to 80%.

The purpose of this study is to verify that the prophylactic use of midazolam, which is a GABA A receptor inhibitor, given five minutes before the end of strabismus surgery reduces the incidence of emergence agitation after sevoflurane anesthesia in children. Simultaneously, this study aims to find out the proper dose of midazolam with minimum disturbance to patient's emergence time.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Korea University Anam Hospital
• Treatments: Midazolam; Sevoflurane

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists physical status I and II patients

• Aged one to 13 years scheduled to undergo strabismus surgery under general anesthesia

• Willing to be assigned to any of the study intervention groups

Exclusion Criteria:

• Refusal by parents

• Neurological disease

• Developmental delay

• History of any previous surgery

• Airway disease

• American Society of Anesthesiologists physical status score of III or IV