A Study on the Interaction Between Danoprevir/Ritonavir and Methadone
Status:
Completed
Trial end date:
2011-07-01
Target enrollment:
Participant gender:
Summary
This multicenter, open-label study will assess the effect of multiple doses of
danoprevir/ritonavir on steady-state pharmacokinetics of methadone. Subjects on stable
methadone maintenance therapy (20 - 120 mg daily as single oral morning dose) will receive
danoprevir 100 mg orally twice daily and ritonavir 100 mg orally twice daily for 10 days.