A Study on the Safety and Efficacy of Nitric Oxide Gel in Subjects With Painful Diabetic Neuropathy

• Status: Completed
• Trial end date: 2013-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a randomized, double-blind, placebo-controlled, 2-period crossover, 12-week trial to be conducted in 50 subjects with painful diabetic neuropathy. The objective of this trial is to assess the safety and efficacy of NO gel, a NO donor, as compared with a placebo gel, in symptom relief of subjects with painful diabetic neuropathy.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: China Medical University Hospital
• Treatments: Ascorbic Acid; Nitric Oxide

Criteria

Inclusion Criteria:

1. Subjects>=30 and<=80 years of age.

2. Subjects with type 1 or type 2 diabetes mellitus with painful diabetic neuropathy.

3. Subjects without undergoing treatment for painful diabetic neuropathy or with treatment for at least 3 months but still presenting neuropathic pain prior to randomization.

4. Subjects who are healthy without any serious diseases that require hospitalization during the study period.

5. Subjects who are capable of understanding and having signed the Informed Consent Form after detailed description of the treatment procedures and potential risks and benefits.

Exclusion Criteria:

1. Subjects with diagnosis of cancer and are still on active therapies.

2. Subjects with diagnosis of an active disease (e.g. hyper-or-hypothyroidism, advanced chronic renal failure, severe anemia, liver cirrhosis, active infectious disease etc.) and are still under regular treatment for this disease

3. Subjects with peripheral neuropathy caused by a known acute or chronic disease or injury

4. Subjects who are on other medications with pharmacological actions that may lead to excessive formation of nitric oxide (e.g. sublingual nitroglycerin, sildanafil etc.) or may accentuate drug effects due to excessive formation of nitric oxide.

5. Subjects with severe peripheral artery disease leading to absence of foot pulses.

6. Subjects with erratic glycemic control (HbA1c 12).

7. Subjects with an active foot ulceration or infection.

8. Subjects with any known allergic reaction to any ingredient in the 2 gel preparations.

9. Subjects who have been enrolled into any clinical study in the preceding 3 months prior to randomization.

10. Subjects with current substance or alcohol abuse that in the opinion of the investigator would interfere with compliance or with interpretation of the study result

11. Female subject of childbearing potential who is lactating or has positive urine pregnancy test at V0 or refuses to adop reliable method of contraception during the study.