A Study to Assess Pharmacokinetics (PK) of Preladenant in Participants With Chronic Renal Impairment (CRI) (P06512)
Status:
Completed
Trial end date:
2011-11-29
Target enrollment:
Participant gender:
Summary
This is a two part study to compare the PK of preladenant administered to participants with
CRI to the PK of preladenant administered to healthy participants. Part 1 will compare the PK
of participants with severe CRI to healthy participants. Part 2 will compare the PK of
participants with moderate CRI and participants with mild CRI to healthy participants. The
primary hypotheses are that the plasma area under the concentration-time curve from time 0 to
infinity after single dosing (AUC0-∞) of preladenant in participants with either severe,
moderate or mild CRI is similar to that of matched healthy participants.