A Study to Assess Safety and Efficacy of Umbilical Cord-derived Mesenchymal Stromal Cells in Knee Osteoarthritis
Status:
Completed
Trial end date:
2017-04-01
Target enrollment:
Participant gender:
Summary
Knee-osteoarthritis (OA) is a common and disabling problem, that represents a global health
issue since none of the current therapies are truly disease modifying. The use of mesenchymal
stem cells (MSCs) in OA-preclinical models has been associated with a reduction in cartilage
degradation, the attenuation of bone sclerosis and an effective anti-inflammatory response.
Investigators have designed a randomized phase I/II placebo controlled trial of UC-MSCs in
knee OA. Outcomes will be evaluated at 12 months, comparing monodosis versus double
intra-articular injection, re-randomized at 6 months.