A Study to Assess the Effect of Concomitant Administration of Fluconazole on the Clinical Pharmacokinetics of Methadone
Status:
Completed
Trial end date:
1994-06-01
Target enrollment:
Participant gender:
Summary
To evaluate the pharmacokinetics and safety of concomitant administration of methadone and
fluconazole.
Injection drug users constitute the second largest subset of the U.S. population at risk for
HIV infection and AIDS-associated mortality. Narcotic addiction is often treated by use of
methadone. Fluconazole has been shown to be highly effective in treating symptomatic mucosal
candidiasis, but it is unknown whether fluconazole affects methadone metabolism, which could
result in symptoms of methadone withdrawal or overdose in patients taking the drugs in
combination.
Phase:
Phase 1
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)