Overview
A Study to Assess the Relative Bioavailability and Effect of Food on the Coated Granule Formulation of Mitapivat in Healthy Participants
Status:
Completed
Completed
Trial end date:
2020-12-03
2020-12-03
Target enrollment:
0
0
Participant gender:
All
All
Summary
The primary purpose of this study is to assess the relative bioavailability of the mitapivat coated granule formulation compared to the tablet formulation following a single oral dose of mitapivat under fasted conditions in healthy adult participants.Phase:
Phase 1Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Agios Pharmaceuticals, Inc.
Criteria
Inclusion Criteria:- Body mass index between 18.0 and 32.0 kilograms per square meter (kg/m^2), inclusive;
- In good health, determined by no clinically significant findings from medical history,
physical examination, 12-lead electrocardiogram (ECG), vital signs measurements, and
clinical laboratory evaluations;
- Females will not be pregnant or lactating, and females of childbearing potential and
males will agree to use contraception;
- Participant has no clinically significant history or presence of ECG findings as
judged by the Investigator at Screening and Check-in.
Exclusion Criteria:
- Significant history or clinical manifestation of any metabolic, allergic,
dermatological, hepatic, renal, hematological, pulmonary, cardiovascular,
gastrointestinal, neurological, respiratory, endocrine, or psychiatric disorder, as
determined by the Investigator;
- History of significant hypersensitivity, intolerance, or allergy to any drug compound,
food, including the 2 soft foods administered in this study, or other substance,
unless approved by the Investigator;
- History of stomach or intestinal surgery or resection including cholecystectomy that
would potentially alter absorption and/or excretion of orally administered drugs
(uncomplicated appendectomy and hernia repair will be allowed);
- History of any malignancy with the exception of non-melanomatous skin cancer in situ,
cervical carcinoma in situ, or breast carcinoma in situ;
- Participant has liver function tests including alanine transaminase (ALT), aspartate
transaminase (AST), alkaline phosphatase, and total bilirubin that are greater than
the upper limit of normal at Screening or Check-in;
- Participant has platelet count or hemoglobin and hematocrit values that are below the
lower limit of normal at Screening or Check-in;
- Confirmed (eg, original value and 2 consecutive repeat measurements) systolic blood
pressure >150 or <90 millimeters of mercury (mmHg), diastolic blood pressure >90 or
<50 mmHg, and pulse rate >100 or <45 beats per minute (bpm);
- Confirmed QT interval corrected for heart rate using Fridericia's method (QTcF) >450
milliseconds (msec) (male participants) or >470 msec (female participants);
- History of active alcoholism or drug/chemical abuse within 2 years prior to Check-in;
- Alcohol consumption of >21 units per week for males and >14 units for females;
- Positive urine drug screen at Screening or positive alcohol breath test result or
positive urine drug screen at Check-in;
- Positive hepatitis panel and/or positive human immunodeficiency virus test;
- Participants with an active infection requiring systemic antimicrobial therapy, or
with an active infection deemed clinically significant by the Investigator during
Screening;
- Participation in a clinical study involving administration of an investigational drug
(new chemical entity) in the past 30 days or 5 half-lives prior to dosing (whichever
is longer);
- Participant has used any over-the-counter medications, including herbal or nutritional
supplements, within 28 days (or 5 half-lives, whichever is longer) before the first
dose of study drug until after the Follow up phone call;
- Participant has used any prescription (excluding hormone replacement therapy and
hormonal birth control) medications within 30 days (or 5 half-lives, whichever is
longer) before the first dose of study drug until after the Follow up phone call;
- Use of tobacco- or nicotine-containing products including cigarettes, snuff, nicotine
patch, nicotine chewing gum, vaporizers, or inhalers, within 6 months prior to
Screening until after the Follow up phone call, or positive cotinine at Screening or
Check-in;
- Participant must refrain from marijuana or cannabinol-containing products for 7 days
before Screening until after the Follow up phone call;
- Ingestion of poppy seed within 7 days prior to Check-in until after the Follow up
phone call;
- Participant has consumed grapefruit or grapefruit juice, Seville orange, or Seville
orange containing products (eg, marmalade) within 7 days before the first dose of
study drug until after the Follow up phone call;
- Participant has consumed caffeine- or xanthine-containing products within 24 hours
prior to first dose of study drug until after the Follow up phone call;
- Participant has consumed vegetables from the mustard green family (eg, kale, broccoli,
watercress, collard greens, kohlrabi, Brussels sprouts, and mustard), or charbroiled
meats for 7 days prior to first dose of study drug until after the Follow-up phone
call;
- Participant is involved in strenuous activity or contact sports from 7 days before
Check-in until after the Follow-up phone call;
- Receipt of blood products within 2 months prior to Check-in;
- Participant has donated blood or blood products >450 milliliters (mL) within 30 days
before the first dose of study drug;
- Participant has a poor peripheral venous access;
- Have previously completed or withdrawn from this study or any other study
investigating mitapivat sulfate, and have previously received the mitapivat sulfate;
- Participant has a history of allergy to sulfonamides (eg, co-trimoxazole antibiotic,
silver sulfadiazine topical antibiotic for burn wounds) that has been characterized by
acute hemolytic anemia, drug-induced liver injury, anaphylaxis, rash of erythema
multiforme type, or Stevens-Johnson syndrome.