A Study to Assess the Safety and Efficacy of an Investigational Drug (MK-686) in Patients With Osteoarthritis (0686-006)

• Status: Completed
• Trial end date: 2006-05-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is being conducted to assess the safety and tolerability of MK-0686 and to evaluate its efficacy in the treatment of osteoarthritis of the hip or knee in men and women.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Merck Sharp & Dohme Corp.

Criteria

Inclusion Criteria:

• Patients with a clinical and radiographic diagnosis of osteoarthritis of the hip or knee,either prior NSAID or Acetaminophen users within the ARA functional class I,II or III and with no clinically significant diseases

• Patients required to demonstrate a flare of the signs and symptoms of OA following withdrawal of NSAID treatment

• Prior acetaminophen users also required to demonstrate greater than a defined minimum level of signs and symptoms of OA

• females must be either post-menopausal or surgically sterilized

Exclusion Criteria:

• No history of concurrent arthritic disease

• No history of neoplastic disease within a specified duration

• No history of disease that causes malabsorption

• Chronic use of certain medications excluded