A Study to Compare Different Antibiotics and Different Modes of Fluid Treatment for Children With Severe Pneumonia
Status:
Suspended
Trial end date:
2023-02-01
Target enrollment:
Participant gender:
Summary
Pneumonia is one of the top causes of death in children aged below 5. More than 10% of
children with severe pneumonia die. We are not sure that the currently recommended
antibiotics used in children with pneumonia are the most effective. No studies have been
carried out to find out whether children with pneumonia should be given intravenous (IV)
fluids or nasogastric (NG) feeds.
The SEARCH trial aims to find out which antibiotics and modes of feeding are the most
effective in treating children with severe pneumonia and therefore helping reduce mortality.
Phase:
Phase 3
Details
Lead Sponsor:
University of Oxford
Collaborators:
Department for International Development, United Kingdom Kenya Ministry of Health London School of Hygiene and Tropical Medicine Medical Research Council National Institute for Health Research, United Kingdom University of Nairobi Wellcome Trust
Treatments:
Amoxicillin Amoxicillin-Potassium Clavulanate Combination Ampicillin Anti-Bacterial Agents Antibiotics, Antitubercular Ceftriaxone Clavulanic Acid Clavulanic Acids Gentamicins Penicillin G Penicillin G Benzathine Penicillin G Procaine Penicillins